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In 1993 the drug company Icos began studying IC351, which is a PDE5 enzyme inhibitor, and this is basically the process through which the erectile dysfunction drugs work.
For most individuals, the recommended starting dose of tadalafil is 10 mg per day taken before sexual activity. The FDA's approval on March 27, 1998, led this prescription drug, Viagra, to a ground breaking success in just the first year of introduction as Pfizer sold drugs worth over a billion dollars.
Eli Lilly purchased ICOS corporation for $21 billion dollars in 2006.
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